Nature Reviews Genetics Contents August 2017 Volume 18 Number 8 pp 453-512

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TABLE OF CONTENTS
August 2017 Volume 18 Number 8
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Also this month Article series: Epigenetics Applications of next-generation sequencing  Featured article: Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells Olivier Cuvier & Beat Fierz
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RESEARCH HIGHLIGHTS Top Non-coding RNA: A protective role for TERRA at telomeres p453 | doi:10.1038/nrg.2017.58 PDF Disease genetics: Repeat expansion disorders — going through a phase p454 | doi:10.1038/nrg.2017.54 PDF Gene expression: Microglia — environment defines identity p454 | doi:10.1038/nrg.2017.55 PDF Cancer epigenetics: Therapy-induced transcription is cryptically widespread p455 | doi:10.1038/nrg.2017.53 PDF Technique: Sizing up tumours with Tuba-seq p456 | doi:10.1038/nrg.2017.50 PDF Cancer genetics: A 3D view of genome rearrangements p456 | doi:10.1038/nrg.2017.56 PDF Genetics JOBS of the week Postdoctoral Position in Mitochondria Biology and Drosophila genetics – FCG at OMRF Oklahoma Medical Research Foundation (OMRF) Faculty Position in Cellular Genetics Wellcome Trust Sanger Institute Faculty Position in Functional Genetics and Genomics University of Pittsburgh Associate Principal Scientist - Cell Engineering Merck & Co. Postdoctoral Fellow | Zhang Lab Monell Chemical Senses Center More Science jobs from Genetics EVENT World Congress on Genetic Counselling 04.10.17 Hinxton, UK More science events from
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Article series: Epigenetics Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells Olivier Cuvier & Beat Fierz p457 | doi:10.1038/nrg.2017.28 A full understanding of chromatin in diverse cellular processes requires the consideration of its dynamics, but most standard chromatin assays provide only a static snapshot. This Review describes various emerging methods for probing chromatin dynamics across a wide range of temporal and spatial scales, and discusses the resulting biological insights. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Reference standards for next-generation sequencing Simon A. Hardwick, Ira W. Deveson & Tim R. Mercer p473 | doi:10.1038/nrg.2017.44 Technical errors can hamper the interpretation of next-generation sequencing (NGS) data, which poses a major challenge for the clinical application of this technology. This Review discusses how reference standards circumvent this issue by calibrating NGS measurements and evaluating diagnostic performance of NGS-based genetic tests. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Human Y-chromosome variation in the genome-sequencing era Mark A. Jobling & Chris Tyler-Smith p485 | doi:10.1038/nrg.2017.36 Genetic variation of the human Y chromosome plays a key part in studies of human evolution, population history, genealogy, forensics and male medical genetics. This Review outlines how next-generation sequencing has contributed to recent progress in these fields. Abstract | Full Text | PDF
The origin of Metazoa: a unicellular perspective Arnau Sebé-Pedrós, Bernard M. Degnan & Iñaki Ruiz-Trillo p498 | doi:10.1038/nrg.2017.21 Multicellular organisms rely on a complex interplay between diverse cell types, but how multicellularity evolved from unicellular ancestors has long been a debated research question. In this Review, the authors describe how comparative and functional genomics have provided valuable insights into the transition between unicellularity and multicellularity, including how various molecular networks have been adopted for multicellular life. Abstract | Full Text | PDF
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